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KMID : 0616120060370030143
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Korean Journal of Pharmacognosy
2006 Volume.37 No. 3 p.143 ~ p.150
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Studies on Pharmaceutical Quality of Oriental Medicinal Preparations (I)-Studies on Decoction of Nokyong-Sagunja-Tang-
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Choi Hyuck-Jae
Kim Eun-Jin
Kim Nam-Jae
Kim Sung-Soo
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Abstract
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Decoction of oriental medicinal preparation is prepared in various manners, and changes of chemical constituents might be occurred depending on the processing techniques. The present study was undertaken to investigate the physio-chem- ical and pharmacological equivalence between two extraction methods of Nokyong-Sagunja-Tang. Samples were prepared as follows ; Sample-I was prepared by simultaneously extacting Ssgunja-Tang and velvet antler in one vessel. Sample-Ⅱ was prepared by adding velvet antler extract to the water extract of Sagunja-Tang. Both samples showed similar results of physiochemical parameters such as pH, yield, TLC and HPLC chromatogram, and contents of ginsenoside Rb1 and glycyrrhizin. Also, there were little different between two samples in pharmacological effects such as DPPH free radical scavenging effect, and inhibitory effects on xanthine oxidase, hyaluronidase, trypsin, TBA-Rs formation and hemolysis in vitro. And both samples showed no significant difference in antifatigue activities in mice. These results suggest that there might be little difference between two extraction process when velvet antler added to Sagunja-Tang.
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KEYWORD
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oriental medicinal preparation, velvet antler, Sagunja-Tang, Nokyong-Sagunja-Tang, ginsenoside Rb1, glycyrrhizin
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